5futhymidylatesynthase

由 A Kumar 著作 · 2022 · 被引用 13 次 — Thymidylate synthase is the rate-limiting enzyme required for DNA synthesis and overexpression of this enzyme causes resistance to cancer cells.

由 SL Showalter 著作 · 2008 · 被引用 111 次 — Thymidylate synthase is a target of 5-fluoruracil, a pyrimidine analog used to treat gastrointestinal and other cancers. The 5-fluorouracil metabolite, ...

由 GJ Peters 著作 · 2002 · 被引用 487 次 — 5FU treatment can induce TS expression, which might bypass dTMP depletion. An improved efficacy of 5FU might be achieved by increasing and prolonging TS ...

由 J Matuszyk 著作 · 2022 · 被引用 14 次 — The network of non-coding RNAs may reduce the sensitivity of cancer cells to 5FU treatment by upregulating the level of thymidylate synthase.

由 A Kumar 著作 · 2022 · 被引用 13 次 — We can overcome 5-FU resistance in cancer cells by regulating thymidylate synthase by natural products (Coptidis rhizoma), HDAC inhibitors, mTOR ...

由 NH Haritha 著作 · 2021 · 被引用 7 次 — Targeting Thymidylate Synthase Enhances the Chemosensitivity of Triple-Negative Breast Cancer Towards 5-FU-Based Combinatorial Therapy.

由 N Very 著作 · 2022 · 被引用 15 次 — Standard treatment for colorectal cancer (CRC), 5-fluorouracil (5-FU), mainly targets Thymidylate Synthase (TS). TS O-GlcNAcylation was ...

由 C Kurasaka 著作 · 2022 · 被引用 9 次 — Thymidylate synthase (TS) is the target enzyme for 5-fluorouracil (5-FU). The authors have correlated TS protein and gene expression with the ...

氟尿嘧啶(5-fluorouracil, 5-FU)作為大腸癌化療的 ... 5-FU 的細胞毒性作用受到胸苷酸合成酶(thymidylate synthase ... 共同形成了獨特的指紋。 Thymidylate Synthase Medicine ...